Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.
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Name of the medicinal product 2.
The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. Minor Due to a possible risk for QT prolongation and torsade de pointes TdPazithromycin and fluphenazine should be decanoatte together cautiously.
Moderate Phenothiazines can potentiate the CNS-depressant action of other drugs such as buspirone. However, abrupt discontinuation of fluphenazine can produce nausea, dizziness, and trembling.
QT prolongation and ventricular arrhythmias, including TdP and death, have been reported with cisapride. For full list of excipients, see section 6. Those with known hypersensitivity to phenothiazines or who are predisposed to undue reactions should have therapy initiated with oral or immediate-release parenteral fluphenazine hydrochloride before receiving fluphenazine decanoate. Concomitant administration of mitotane and CNS depressants, including opiate agonists, may cause additive CNS effects.
Theoretically, fluphenazine may increase the risk of QT prolongation if coadministered with other drugs that have a risk of QT prolongation. Phenothiazines readily cross the placenta. Minor Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering lopinavir; ritonavir with fluphenazine.
CNS depressants can potentiate the effects of cannabidiol. Hematologic effects including leukopenia, neutropenia, and agranulocytosis have been associated with antipsychotic use.
Minor Fluphenazine should be used cautiously and with close monitoring with methadone. The response to antipsychotic drug treatment may be delayed. Minor Both fluphenazine and ciprofloxacin are associated with a possible risk for QT prolongation; therefore, caution is advised when administering these medications concurrently.
Treatment of non-acute, chronic, or prolonged BPSD must meet all of the OBRA criteria for BPSD treatment, and include monitoring that ensures the behavioral symptoms are not due to a treatable or correctable medical condition, are not due to correctable environmental or treatable psychological stressors alone, and provides clearly documented evidence of persistence.
Drugs with a possible risk for QT prolongation that should be used cautiously and with close monitoring with lapatinib include fluphenazine.
Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation.
However, the syndrome can develop, although much less commonly, after relatively brief periods at low doses or may even arise after drug discontinuation. If a phenothiazine and carbamazepine must be used together, dosage adjustments of the phenothiazine may be required. According to the manufacturer, since iloperidone may prolong the QT interval, it should not be used with other agents also known to have this effect, such as fluphenazine.
Antiarrhythmics, disopyramide, procainamide, quinidine: Severe Coadministration of cisapride and fluphenazine is contraindicated due to the risk for serious adverse events, such as torsade de pointes TdP. The phenothiazines are noted to result in a decreased efficacy of bromocriptine.
The in use shelf life for the 10ml vial is 28 days. May result in hypotension.
Subcutaneous injection fluphenazine decanoate or fluphenazine enanthate: Moderate Concomitant use of pentazocine with other CNS depressants, such as phenothiazines, can potentiate respiratory depression, CNS depression, and sedation.
Consider a dose reduction of one or both drugs. At high doses, loperamide has been associated with serious iinsert toxicities, including syncope, fouphenazine tachycardia, QT prolongation, torsade de pointes TdPand cardiac arrest.
The likelihood of QTc prolongation may increase with increasing dose of gemifloxacin; therefore, the recommended dose should not be exceeded especially in patients with renal or hepatic impairment where the Cmax and AUC are slightly higher.
Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)
Although there are no studies examining the effects of dronedarone in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation.
Moderate Concurrent use of tramadol and fluphenazine should be avoided if possible. Some human flyphenazine cancers may be prolactin-dependent and therefore phenothiazines should be used extremely cautiously in patients who have a history of breast cancer. The phenothiazines should be prescribed in the smallest quantity consistent with good patient management in dedanoate to reduce the risk of overdose.
Flupyenazine out more here. Fluphenazine is also associated with a possible risk for QT prolongation. Lapatinib should be administered with caution to patients who have or may develop prolongation of QTc such as patients taking anti-arrhythmic medicines or other medicinal products that lead to QT prolongation.
Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. Fluphenazine HCl is administered via IM injection only, do not administer intravenously or subcutaneously. Coadministration may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures.
As benzyl alcohol may packag the placenta, solution for injection should be used with caution in pregnancy.
Minor Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering bedaquiline with fluphenazine. If fluphenazine therapy is needed, it should be initiated with a low dosage and titrated upward slowly to desired clinical effect.
Recurrence of NMS has been reported with resumption of drug therapy. There are insufficient data to give a firm estimate of the precise magnitude of the risk and the cause of the increased risk is not known.
However, if irritation occurs, subsequent IM doses may edcanoate diluted with 0. Solution for Injection Pale yellow clear, oily liquid. Caution should be exercised with the following: A transient rise in serum cholesterol has been reported rarely in patients on oral fluphenazine. As with other phenothiazines, drowsiness, lethargy, blurred vision, dryness of the mouth, constipation, urinary hesitancy or incontinence, mild hypotension, impairment of judgement and mental skills, and epileptiform attacks are occasionally innsert.
Monitor for sedation and respiratory depression. The likelihood of these pharmacodynamic interactions varies based upon the individual properties of the coadministered antipsychotic agent, with low-potency agents e. Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as diphenhydramine, a sedating H1-blocker.