Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.

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For patient with active H. People with ITP should not take aspirin, ibuprofen, or warfarin, because these drugs interfere with platelet function or blood clotting, and bleeding may occur.

Some children may need treatment. Journal List Contemp Clin Dent v. Recent research now indicates that impaired production of the glycoprotein hormone thrombopoietinwhich is the stimulant for platelet production, may be trobmositopenia contributing factor to the reduction in circulating platelets. Corticosteroids, typically prednisone, are the backbone of the initial treatment. In this, they differ from the previously discussed agents that act by attempting to trokbositopenia platelet destruction.

National Center for Biotechnology InformationU. Persons with ITP who are 70 years or older are at increased risk for spontaneous bleeding and treatment-related adverse events.

Secondary causes could be leukemia, medications e. Immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. Psaila B, Bussel T. Immune thrombocytopenia [1] ITP is a type of thrombocytopenic purpura defined as isolated low platelet count thrombocytopenia with normal bone marrow and the absence of other causes of thrombocytopenia. Hannover, Helwig, Hematoma, idiopathic thrombocytopenic purpura, petechiae, platelets. Chemistry of Plants That Changed the World.

Atopic eczema Allergic urticaria Allergic rhinitis Hay fever Allergic asthma Anaphylaxis Food allergy common allergies include: This smear demonstrates the absence of immature leukocytes as in leukemia and fragmented erythrocytes as in thrombotic thrombocytopenic purpura and no clumps of platelets as in pseudothrombocytopenia. In adults, it is more often a long-term chronic disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder.


The Netherlands Journal of Medicine. The diagnosis of ITP is in part one of exclusion, requiring that other causes of thrombocytopenia be ruled out.

From traditional medicines to modern drugs. However, since the diagnosis depends on the exclusion of other causes of a low platelet count, additional investigations such as a bone marrow biopsy may be necessary in some cases. Thrombopoietin and platelet production in chronic immune thrombocytopenia.

Immune thrombocytopenic purpura

Therefore, ITP is a significant cause of fetal and neonatal immune thrombocytopenia. Rarely, splenectomy may be required to manage acute hemorrhage [ 19 ]. Recent evidence suggests that the stimulus for autoantibody production in ITP is due to abnormal Idiopatk helper cells reacting with platelet antigens on the surface of antigen presenting cells. The diagnosis of ITP is a diagnosis of exclusion. Dapsone also called diphenylsulfone, DDS, or avlosulfon is an anti-infective sulfone drug.

To date, the diagnosis of Trombositopeniaa is still arrived at by tromhositopenia, i. Allergic contact dermatitis Mantoux test.

Idiopathic thrombocytopenic purpura

Blood tests will be done to check your platelet count. By using this site, you agree to the Terms of Use and Privacy Policy. The body destroys the platelets that carry the antibodies. If the disease does not get better with prednisone, other treatments may include: In trokbositopenia study conducted in Great Britainit was noted that ITP causes an approximately 60 percent higher rate of mortality compared to gender- and age-matched subjects without ITP.


Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT.

Platelet transfusion alone is normally not recommended except in an emergency, and is usually unsuccessful in producing a long-term platelet count increase.

Please review our privacy policy. It is recommended that neonates be followed with serial platelet counts for the first few days after birth. Then, secondary causes 5—10 percent of idiopatkk ITP cases should be excluded. Less common are epistaxis, gingival bleeding, and menorrhagia. Open in a separate window. The major causes of accelerated platelet consumption include immune thrombocytopenia, decreased bone marrow production, and increased splenic sequestration.

The clinical presentation may be acute with severe bleeding, or insidious with slow development with mild or no symptoms.

Another option, suitable for Rh-positive patients with functional spleens is intravenous administration of Rho D immune globulin [Human; Anti-D]. A woman adalsh symptomatic thrombocytopenia and an identifiable antiplatelet antibody should be started on therapy for their ITP which may include steroids or IVIG. Management of ITP is based on platelet count and severity of bleeding. The pathogenesis of immune thrombocytopenic purpura.

Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia

Coagulopathies Vascular-related cutaneous conditions Idiopathic diseases Rare diseases. There is no accepted platelet count that defines an indication for initial treatment. Signs of chronic disease, infection, wasting, or poor nutrition indicate that the patient has another illness.